Callular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells / Heussler, V.T

Public ISBD Faire une suggestion d'achat Titre : Callular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells Type de document : texte imprimé Auteurs : Heussler, V.T, Auteur Importance : pp. 211-218 Langues : Anglais (eng) Index. décimale : 616 Maladies Résumé : Apicomplexan parasites of the genera Theiierio and Plasmodium hove complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host. As the Plasmodium parasite progresses through its life cycle, it enters a number of different cell types, both in its mammalian and mosquito hosts. The fate of these cells varies greatly, as do the parasite and host molecules involved in parasite-host interactions. In mammals, Plasmodium parasites infect hepatocytes and erylhrocytes whereas Theileria infects ruminant leukocytes and erythrocytes. Survival of Plasmodiumum-infected hepatocytes and Theileria-infected leukocytes depends on parasite-mediated inhibition of host cell apoptosis but only Theileria -infected cells exhibit a fully transformed phenotype. As the development of both parasites progresses towards the merozoite stage, the parasites no longer promote the survival of the host cell and the infected cell is finally destroyed to release merozoites. In this review we describe similarities and differences of parasite-host celt interactions in Plasmosium-infected hepatocytes and Theileria-infected leukocytes and compare the observed phenotypes to other parasite stages interacting with host cells. Callular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells [texte imprimé] / Heussler, V.T, Auteur . - [s.d.] . - pp. 211-218. Langues : Anglais (eng) Index. décimale : 616 Maladies Résumé : Apicomplexan parasites of the genera Theiierio and Plasmodium hove complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host. As the Plasmodium parasite progresses through its life cycle, it enters a number of different cell types, both in its mammalian and mosquito hosts. The fate of these cells varies greatly, as do the parasite and host molecules involved in parasite-host interactions. In mammals, Plasmodium parasites infect hepatocytes and erylhrocytes whereas Theileria infects ruminant leukocytes and erythrocytes. Survival of Plasmodiumum-infected hepatocytes and Theileria-infected leukocytes depends on parasite-mediated inhibition of host cell apoptosis but only Theileria -infected cells exhibit a fully transformed phenotype. As the development of both parasites progresses towards the merozoite stage, the parasites no longer promote the survival of the host cell and the infected cell is finally destroyed to release merozoites. In this review we describe similarities and differences of parasite-host celt interactions in Plasmosium-infected hepatocytes and Theileria-infected leukocytes and compare the observed phenotypes to other parasite stages interacting with host cells.

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