Accumulation and elimination kinetics of dietary endosulfan in atlantic salmon (salmo salar) / Chris N. Glover

Public ISBD Faire une suggestion d'achat Titre : Accumulation and elimination kinetics of dietary endosulfan in atlantic salmon (salmo salar) Type de document : texte imprimé Auteurs : Chris N. Glover, Auteur Importance : pp. 104-111 Langues : Anglais (eng) Index. décimale : 571 Physiologie et sujets voisins Résumé : The carry-over of dietary endosulfan to (he fillet of farmed Atlantic salmon was studied. The uptake and elimination rale constants of the a and (3 isoform of endosulfan were determined in seawatcr adapted Atlantic salmon (initial weigh 173 ± 25 g) fed on endosulfan enriched diets (724 and 315(jLgkg-1 for a-and p-endosiilfan, respectively) for 92 days, followed by a 56 days depuration period with feeding on control diets (<0.3 j-ig kg-1 endosulfan). The accumulation of the toxic metabolite endosulfan sulphate, which was not detected (<0.5 ug kg-1) in the experimental feeds, was also determined. Dietary pl-endosulfan was more persistent than a-endosulfan as demonstrated by a higher uptake (41 ±8% vs. 21 ±2%) and lowcrelimination(26±2 x 10~3day~' vs.40± 1 x 10~3day~1)raieconstants,andahigherbiomagnificationfactor(0.lO±0.026vs.0.05±0.003, p<0.05). Based on the decrease in diasiercometric factor over time, biotransformation was estimated to account for at least 50% of the endosulfan elimination. The formation of the metabolite endosulfan sulphate comprised a maximum 1.2% of the total accumulation of endosulfan. Using a simple one-comparlmcntal model and the experimentally-determined rate constants, it was predicted that only dietary concentration higher than 7.5 mg kg-1 would cause the estimated maximum residue level (MRL) in fillet of 0.47 mg kg to be exceeded. Model estimations also predict that current EU maximum permitted levels in fish feeds (0.005 mg kg-1 would give fillet concentrations that arc under the detection limit (0.3 jxg kg-1), which is in agreement with the general absence of endosulfan in monitored farmed Atlantic salmon. Accumulation and elimination kinetics of dietary endosulfan in atlantic salmon (salmo salar) [texte imprimé] / Chris N. Glover, Auteur . - [s.d.] . - pp. 104-111. Langues : Anglais (eng) Index. décimale : 571 Physiologie et sujets voisins Résumé : The carry-over of dietary endosulfan to (he fillet of farmed Atlantic salmon was studied. The uptake and elimination rale constants of the a and (3 isoform of endosulfan were determined in seawatcr adapted Atlantic salmon (initial weigh 173 ± 25 g) fed on endosulfan enriched diets (724 and 315(jLgkg-1 for a-and p-endosiilfan, respectively) for 92 days, followed by a 56 days depuration period with feeding on control diets (<0.3 j-ig kg-1 endosulfan). The accumulation of the toxic metabolite endosulfan sulphate, which was not detected (<0.5 ug kg-1) in the experimental feeds, was also determined. Dietary pl-endosulfan was more persistent than a-endosulfan as demonstrated by a higher uptake (41 ±8% vs. 21 ±2%) and lowcrelimination(26±2 x 10~3day~' vs.40± 1 x 10~3day~1)raieconstants,andahigherbiomagnificationfactor(0.lO±0.026vs.0.05±0.003, p<0.05). Based on the decrease in diasiercometric factor over time, biotransformation was estimated to account for at least 50% of the endosulfan elimination. The formation of the metabolite endosulfan sulphate comprised a maximum 1.2% of the total accumulation of endosulfan. Using a simple one-comparlmcntal model and the experimentally-determined rate constants, it was predicted that only dietary concentration higher than 7.5 mg kg-1 would cause the estimated maximum residue level (MRL) in fillet of 0.47 mg kg to be exceeded. Model estimations also predict that current EU maximum permitted levels in fish feeds (0.005 mg kg-1 would give fillet concentrations that arc under the detection limit (0.3 jxg kg-1), which is in agreement with the general absence of endosulfan in monitored farmed Atlantic salmon.

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